Instead, the downregulation of X-linked inhibitor of apoptosis (XIAP) and survivin, two pro-survival proteins, under Rac inhibition by NCS23766 was shown to promote cell death in triple-negative breast cancer cells regardless of Bcl2 and cyclin D1 expression (Yoshida et al. 2010). The gene discussed is CCND1; the disease is triple-negative breast carcinoma.