AKT1 and breast carcinoma: To investigate the potential of HV-107 to inhibit Rac activity in breast cancer cells, MDA-MB-231 and MDA-MB-468 cell lines were chosen due to their different levels of Rac expression and activation: MDA-MB-231 presents an overexpression of Rac, while MDA-MB-468 is characterized with abundant expression of Rac1b (Melzer et al. 2019).