PTK2 and cancer: Furthermore, the study demonstrated that HV-107 also affected Pyk2 and FAK signalling in TNBC cells, which are crucial regulators of migration and extracellular matrix degradation in various cancers (Naser et al. 2018; Chan et al. 2009; Genna et al. 2018; Chang et al. 2007; Tomar and Schlaepfer 2010).