In a focused study of FL, 11% of a cohort of 114 follicular lymphomas had somatic STAT6 GOF mutations with most mutations occurring at the DNA binding interface of STAT6 and the most frequent somatic mutations occurring at amino acid 419, which was described as a hotspot for genetic mutation (D419G, D419A, and D419H) [33]. The gene discussed is STAT6; the disease is follicular lymphoma.