IGHE and Increased total eosinophil count: The proband’s mother presented in early childhood with severe eczema and other typical atopic disease manifestations, including eosinophilia (20% of total white cell count, 1.74 × 109/L, normal range 0–0.5 × 109/L), elevated IgE fluctuating between 7000 to 14,000 IU/ml, multiple food allergies and asthma.