Monocyte chemotactic protein 1 (MCP-1) or CCL2 is a potent chemoattractant of macrophages and monocytes62,63 and due to their ability to recruit eosinophils, monocytes, activating mast cells and basophils, they may play significant role in asthma pathogenesis64,65. This evidence concerns the gene CCL2 and asthma.