CD4 and neoplasm: Flow cytometric analyses of tumour-infiltrating immune cells at days 2, 5 and 8 after adoptive CD4+ T cell transfer confirmed the dynamic recruitment of Ly6c-hi immature monocytes into the tumour microenvironment on CD4 ACT therapy and their differentiation into iNOS-expressing tumouricidal mononuclear phagocytes (Fig. 3f and Extended Data Fig. 7g,h).