JAK1 and neoplasm: Treatment with the highly specific iNOS inhibitor (N6-(1-iminoethyl)-l-lysine, L-NIL) abrogated the ability of CD4 ACT treatment to control IFN-unresponsive, MHC-deficient HCmel12 Jak1-KO tumours, but had no effect on CD4 ACT treatment of IFN-responsive, MHC-deficient HCmel12 Ciita-KO tumours (Fig. 4b,c and Extended Data Fig. 9a,b).