Together, the flow cytometric and transcriptomic analyses indicated that CD4+ T cells and innate immune stimuli reprogramme the myeloid network in treated tumours through the recruitment of immature monocytes that acquire IFN-activated cellular states and dynamically differentiate towards MHC-II antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Here, IFNA1 is linked to neoplasm.