Hippe et al. revealed that the EGFR/Ras activation increases the expression level of CCL20 and promotes CCL20 production in a large group of tumor cell lines, among others breast cancer, melanoma, head and neck squamous cell carcinoma, changing cells from a resting phenotype into a proliferative and migratory one47. This evidence concerns the gene CCL20 and head and neck squamous cell carcinoma.