In summary, we demonstrated that ABCA1 deficiency in podocytes, which contributes to DKD progression, induces the expression of non-canonical pyroptosis-related genes such as caspase-4/11, GSDMD, caspase-1 and IL1β via nuclear APE1 accumulation and subsequent reduction of transcription factors. The gene discussed is GSDMD; the disease is diabetic kidney disease.