According to our findings, the expression of PUS1, PUS7, DKC1 and RPUSD1 is highly expressed in most cancer types, and among those genes, the expression of PUS1, PUS7 and RPUSD1 is markedly upregulated in renal cancers, including KICH, KIRC and KIRP (Figure 1A, 1B). The gene discussed is PUS1; the disease is cancer.