GIST are believed to originate from the interstitial cells of Cajal, or a precursor cell, along the GI tract.17,18 Morphology, they can be either spindled (70%), epithelioid (20%), or mixed (10%), and typical immunohistochemical markers include CD117 and DOG1.17-21. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.