Thus, not only is the SRSF3 NMD+ isoform translated in DUX4-expressing cells, its protein product, SRSF3-TR can be detected in both DUX4-expressing MB135-iDUX4 myoblasts and in FSHD patient-derived myotubes. The gene discussed is SRSF3; the disease is facioscapulohumeral muscular dystrophy.