POMC and Cowden syndrome 1: Among female patients with ACTH-dependent CS, those with CD had higher HCT (median 43.3 vs 36.1%), RBC count (4.8 vs 4.0 n*106/μl), and Hb (14.3 vs 12.2 g/dl) than those with ECS (p < 0.0005 in all cases).