In response to stress stimuli, a trimolecular complex containing TP53/MDM2/GR is formed where MDM2 suppresses the transcriptional activity of GR leading to apoptosis in mammary epithelial cells, vascular endothelial cells, and liver cells while enhancing survival in lymphocytes, lymphoma, and leukemia [72]. Here, NR3C1 is linked to leukemia.