21 days after tumor cell inoculation, flow-cytometry combined with RT-qPCR analyses showed that Ccr7 and Ccl21 transcripts were detected in CD45−GFP+ CT2A tumor cells and CD45+CD11b+CD3− myeloid cells (Fig. 1f), suggesting that CCL21 may activate tumor cells and TAMs via autocrine or paracrine signaling. Here, CCL21 is linked to neoplasm.