Interestingly, microglial cells treated with CM from shCCL21 knockdown tumor cells downregulated cytokines associated with angiogenesis (angiopoietin 2, MMP9, MMP2, Col18a1), tumor invasiveness (MMP9 and MMP2) and tumor-supportive TAMs (CSF-1, CCL5, CXCL2) when compared to microglia treated with CM from shCTRL cells. This evidence concerns the gene MMP9 and neoplasm.