With respect to the gene expression profile, CCL21 increased the expression of tumor-supportive genes such as Vegfa, Mrc1, Arg1, and Cd274 (PD-L1) in microglia (Fig. 3a), as well as in BMDMs that also showed increased expression of Il-10 and Tgfβ1 (Fig. 3b) [16, 18, 48]. Here, CD274 is linked to neoplasm.