SLC2A1 and glioblastoma: Using glucose transporter 1 (Glut1) immunostaining to detect both hypoxic areas within the tumor mass and active glucose transport in blood vessels, we found that mice with shCCL21a-transduced tumors displayed less hypoxic brain areas and more Glut1 coverage of blood vessels compared to mice bearing shCTRL-transduced GBM, indicating a benefit on blood–brain barrier function (Fig. 7d, e, Supplementary Fig. 6e).