CDKN2A and acute lymphoblastic leukemia: The absence of CDKN2A/B may indicate poor prognosis in adult and pediatric ALL patients, which may be related to the pathogenesis of the disease (Ribera et al. 2017; Qian et al. 2019; Braun et al. 2017; Zhang et al. 2019; Kumari et al. 2022).