This percentage is higher than even the highest estimate of MOR-expressing preBötC neurons (Baertsch et al., 2021), suggesting dorsolateral pontine neurons preferentially target MOR-expressing glutamatergic preBötC neurons, which are important mediators of inspiratory rhythm generation and opioid-induced respiratory depression in medullary slices (Sun et al., 2019; Bachmutsky et al., 2020). The gene discussed is OPRM1; the disease is respiratory depression.