Specific examples of this circadian regulation include the diurnal variation in eosinophils [28], the circadian regulation of the expression of IL-6 and IL-13 in mast cells expressing high affinity IgE receptor (FceRI) [29] and the circadian regulation of basophil degranulation in response to IgE ligation in asthma [30]. The gene discussed is IGHE; the disease is asthma.