GPX4 and neoplasm: There has been a study reporting that silencing of lncRNA NEAT1 can act in combination with erastin to down-regulate SLCA11 and GPX4, induce ROS increase, and promote the upregulation of Bax and caspase-3, inhibit the expression of Bcl-2, which motivates ferroptosis and apoptosis, and inhibits tumor proliferation, metastasis and invasion in non-small cell lung cancer (135).