GSDMD expression is decreased in gastric cancer tissues, and S/G2 cell transition is accelerated by activating signal transducer and activator of transcription-3 (STAT3) and phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway to regulate cell cycle-related proteins and promote tumor proliferation in vitro and in vivo (71). This evidence concerns the gene STAT3 and gastric cancer.