PVT1 and hepatocellular carcinoma: Enhancer of Zeste Homolog-2 (EZH2) negatively correlates with lncRNA PVT1 in hepatocellular carcinoma cells, and lncRNA PVT1 can increase methylation of the ZBP1 promoter and promote necroptosis by combining with DNA methyltransferase-1 through EZH2 (57, 58).