In particular, the activity of the protein MYSM1 (Myb-like, SWIRM, and MPN domains-containing protein 1), a histone H2A DUB reported to induce H2A deubiquitination and activation of several target genes in cancer, has been shown to regulate NK cell maturation downstream of IL-15 signaling, with no activity on NK lineage specification and early development (Nandakumar et al., 2013). Here, MYSM1 is linked to cancer.