With this constraint, the 5 alleles with the largest AF ratios were: B*39:09g (fCL-MP fCL-NI=1.691, fCL-NI=0.096, fCL-MP=0.163), DRB1*16:02g (fCL-MP fCL-NI=1.562, fCL-NI=0.047, fCL-MP=0.074), DRB1*14:02g (fCL-MP fCL-NI=1.512, fCL-NI=0.044, fCL-MP=0.067), DPB1*01:01g (fCL-NI fCL-MP=1.510, fCL-NI=0.036, fCL-MP=0.024), and B*35:09 (fCL-MP fCL-NI=1.491, fCL-NI=0.031, fCL-MP=0.046). This evidence concerns the gene HLA-DRB1 and atrial fibrillation.