The ELISA results revealed that the levels of nine immune-related proteins (A2M, C3, CAT, IGKV1-5, LTF, MMP9, RBP4, S100A6, and SERPINA3) were significantly higher in the CRC group than in the HC group (P< 0.05). The gene discussed is IGKV1-5; the disease is colorectal carcinoma.