PDHA1 and systemic lupus erythematosus: SLE samples presented higher expression of NFE2L2, NLRP3, ATP7A, MTF1, and CDKN2A genes and lower expression of LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GLS, DBT, and DLST genes versus the Control group (Figures 2A, B).