CD8A and systemic lupus erythematosus: The CIBERSORT algorithm revealed a significant distinction in the proportions of 22 kinds of immune cells between the Control and SLE groups such as neutrophils, plasma cells, CD8+ T cells, naive CD8+ lymphocytes, M1 macrophages, activated dendritic cells (DC), resting mast cells, etc. (Figures 2D, E), suggesting that immune system alteration might be the primary cause of SLE occurrence.