In murine and cynomolgus monkey tumor models, BisAb has been shown to induce a unique activation of the innate immune system, involving the pattern recognition receptor-mediated type I interferon pathway, as well as antigen presentation by DCs and macrophages; this has been shown to promote the differentiation of progenitor CD8 T cells into effector T cells and alter the immune status in the TME (153). Here, CD8A is linked to neoplasm.