CD274 and ovarian carcinoma: In clinical samples of ovarian cancer, PD-L1+ CD68+ macrophages have been elucidated to express higher levels of IL-10, IL-6, compared to PD-L1- CD68+ macrophages; moreover, PD-L1 binding to T cells PD-1 has been demonstrated to induce apoptosis of T cells, thereby facilitating immune escape (70).