Myeloma cells secreted IL-32γ-containing exosomes, which upregulated the expression of PD-L1 on macrophages by increasing the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), ultimately facilitating immune evasion (80). The gene discussed is PFKFB3; the disease is plasma cell myeloma.