TAMs have been implicated in a variety of processes in: (1) promotion of tumorigenesis and progression through cancer-associated inflammation (15), (2) introduction of tumor metastasis through involvement in epithelial-mesenchymal transition (EMT) regulation (16), angiogenesis and remodeling, and tumor cell intravasation (17–19), and (3) inhibition of T cell activity, secretion of cytokines such as IL-10, and expression of immune checkpoint ligands, thereby promoting immunosuppression of TME (20, 21). This evidence concerns the gene IL10 and neoplasm.