PDCD1 and mesothelioma: demonstrated that, in mesothelioma mouse models, BLZ945 inhibited the progression of mesothelioma, eliminated infiltration of TAMs and MDSCs, promoted the polarization of TAMs to the M1 phenotype, and stimulated the activation of CD8+ T cells; however, it also caused a compensatory increase in PD-L1 expression on macrophages and DCs and PD-1 immune escape signals on CD8+ T cells.