CD47 and neoplasm: Direct blockade of CD47 on tumor cells via the binding of the Fc segment of CD47 IgG1 antibody to FcγR on macrophages neutralized the inhibitory CD47 signaling and activated antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which has a significant inhibitory effect on tumor cells, such as leukemic cells in non-human primate (141).