These studies have found significant associations between genetic variants in SHROOM3 and CKD, baseline estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (uACR), and blood urea nitrogen.3,13, -15 Studies investigating mouse models with varying Shroom3 expression levels support these findings and attempt to uncover the cause of these significant associations to further understand the role of Shroom3 in the kidneys. Here, SHROOM3 is linked to chronic kidney disease.