The study aimed to evaluate the diagnostic accuracy of p16INK4a/Ki-67 DS in cervical cytology to identify high-grade CIN (CIN2+) in women participating in opportunistic cervical cancer screening in Georgia, compare it with Pap test results and determine the role of integration of biomarkers in cytology-based screening. Here, MKI67 is linked to cervical squamous intraepithelial neoplasia.