Our study revealed a statistically significant correlation between p16INK4a/Ki-67 DS in cervical cytology and histopathology results of high-grade dysplasia of the uterine cervix (p = 2.5 × 10−6 or p < <0.01); In the study sensitivity of p16INK4a/Ki-67 DS cytology, regardless of the morphology of stained cells, in detecting histologic CIN2+ (CIN2 and CIN3) was 100% (Table 10), which is comparable with several other studies [31, 32, 34]. The gene discussed is MKI67; the disease is dysplasia.