During postnatal life, factors such as diet, physical activity, sleep– wake cycle and various environmental factors lead to changes in the epigenome and contribute to the risk of developing T2DM in the future.15 An important RNA-binding protein, NONO, is an epigenetic regulator of genes, controlling various pathways of carbohydrate and fat metabolism in the liver in accordance with the availability of nutrition.19 NONO is pivotal in predicting an individual’s risk of developing T2DM.15,19. The gene discussed is NONO; the disease is type 2 diabetes mellitus.