Considering that diabetes might represent a serious predisposing factor in reducing insulin sensitivity and increasing IR and hyperinsulinemia, it has been suggested that the administration of inositols may depend on the ability of epimerase to convert MYO into DCI in an adequate quantity.45,46 In the absence of such familial predisposition, the administration of MYO is plausible alone47 or in combination with DCI;48 nonetheless, DCI integration plays a relevant role in the presence of familial diabetes.8,43–46. Here, INS is linked to diabetes mellitus.