Indeed, patients with PCOS with familial diabetes showed a higher IR than patients with PCOS without familial diabetes when undergoing OGTT.84 As C-peptide response did not differ between the two PCOS groups, HIE resulted higher in patients with PCOS with familial diabetes for almost the whole duration of the OGTT, mainly due to the reduced hepatic clearance of insulin.84 Recently, the integrative approach to treating PCOS using ALA alone63 or in combination with MYO66 or DCI67 demonstrated great efficacy, especially in patients with PCOS with a familial predisposition to diabetes.68 The gene discussed is INS; the disease is diabetes mellitus.