MAPT and Alzheimer disease: Although dominant for over three decades, the hypothesis that Aβ cascade is directly responsible for AD is being challenged strongly.58 Aside from fraudulent research, as recently revealed in Science,59 it is also known that many people with no clinical manifestations of dementia actually have neuropathological hallmarks of AD.58 Moreover, from the analysis of 14 anti-Aβ drug clinical trials, targeting Aβ and tau does not appear to improve cognitive functions in people with AD.60