Sodium-glucose co-transporter 2 (SGLT2) inhibitors are now widely used for treating T2DM, especially in people with cardiorenal complications.80 Their use is associated with reduced risk of dementia in people with T2DM; data from the recent nested case-control study by Wium-Andersen et al. indicate that this class of drug actually has neuroprotective effects.81 The study enrolled 176,250 people with T2DM registered in the Danish National Diabetes Register. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.