WNT3A and Insulin resistance: A study conducted by Lee et al. in 2014 showed that regular swimming significantly reduced fat percentage and fat-free mass, and significantly enhanced physical fitness, muscular endurance, flexibility and right leg vascular compliance.110 Although aquatic exercises improve blood glucose level, physical fitness and overall cardiovascular health, it is recommended to not overdo the exercise or practice when feeling nauseous, fatigued, dizzy, weak, etc.110,111 Interestingly, swimming could be a potent ameliorator for insulin resistance in T2DM, via the Wnt3a/β-catenin pathway.112