In response to glucose loading, individuals with T2D display delayed insulin secretion as well as failure of glucagon suppression, contributing to postprandial hyperglycaemia.31 GLP-1-mediated suppression of glucagon secretion is thus expected to augment its insulinotropic effect in normalizing postprandial hyperglycaemia.32 The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.