On the contrary, a study where IF was followed for 12 months reported significant reductions in fasting insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) levels in the alternate-day fasting group.44 Similarly, another systematic review found that IF reduces participants’ FBG levels.41 Studies have also reported that insulin decreases because of increased insulin sensitivity and, hence, decrease fasting and postprandial blood glucose in patients with diabetes.40,44. This evidence concerns the gene INS and diabetes mellitus.