In several studies, metformin increased BCL2L11 expression and, for instance, inhibited growth of EC cell line RL95-2 after treatment with 4.0 mmol/L for 48 h [126], induced apoptosis at 1.0 mmol/L after 48 h in H1975 and PC-9 lung cancer cell lines [127] or inhibited proliferation of esophageal cancer cell lines Eca109 and EC9706 at 10.0–20.0 mmol/L after 24 h [128]. Here, BCL2L11 is linked to esophageal cancer.