For MMP10, another metastasis-promoting matrix metalloproteinase [78,79], downregulation was achieved in Ishikawa cells with 1.0 mmol/L metformin during hyperglycemia, while 0.1 mmol/L metformin was more favorable under normoglycemic conditions, particularly in combination with insulin; the MMP10 transcript could not be detected in HEC-1A cells. The gene discussed is INS; the disease is Hyperglycemia.