Hyperinsulinemia moderately downregulated the expression of APC (FCNG, ins = 0.57), CDKN1A (FCNG, ins = 0.61, p = 0.033 vs FCNG, 1.0), CEACAM1 (FCNG, ins = 0.86, p = 0.029 vs FCNG, 0.1) and IGF1 (FCNG, ins = 0.68) under normoglycemic conditions, and more remarkably of BCL2L11 (FCNG, ins = 0.51, p = 0.007, p = 0.003 vs FCNG, 0.1 and p = 0.028 vs FCNG, 1.0), CASP8 (FCNG, ins = 0.48, p = 0.099), CDH1 (FCNG, ins = 0.38, p = 0.001, p = 0.056 vs FCNG, 0.1), PTEN (FCNG, ins = 0.43, p = 0.013), RAC1 (FCNG, ins = 0.54, p = 0.069 vs FCNG, 0.1) and TGFB1 (FCNG, ins = 0.58). This evidence concerns the gene CASP8 and hyperinsulinism.