CDH1 and Hyperglycemia: Keeping that in mind, effects of metformin treatment during hyperglycemia were similar to the effects observed in a normoglycemic milieu for BCL2L11 (FCHG, 0.1 = 1.28; FCHG, 1.0 = 1.19), COL1A1 (FCHG, 0.1 = 1.12; FCHG, 1.0 = 1.55) and MMP9 (FCHG, 0.1 = 0.74; FCHG, 1.0 = 0.51), whereas CDH1 (FCHG, 0.1 = 1.60; FCHG, 1.0 = 1.92) and PTEN (FCHG, 0.1 = 2.16; FCHG, 1.0 = 1.82) levels were not affected by metformin under the influence of hyperglycemia.