PTEN and hyperinsulinism: In contrast, CDH1 (FCHG, ins = 1.52), CDKN1A (FCHG, ins = 2.87), PTEN (FCHG, ins = 1.61) and MMP9 (FCHG, ins = 0.71) were slightly downregulated during hyperinsulinemia under the influence of a hyperglycemic environment, when compared to the respective untreated hyperglycemic control samples.