Existing research has identified NLRC3 as a factor involved in host immunity against pathogens such as bacteria and parasites, attenuating autoimmunity by downregulating antigen-presenting function of dendritic cells through the p38 signaling pathway (Zhang et al., 2019b; Wang et al., 2019; Vargas-Lagos et al., 2019; Hu et al., 2018; Fu et al., 2019). This evidence concerns the gene NLRC3 and Autoimmunity.