Cytosolic hCA II and transmembranehCA XII isoforms are upregulated in glaucoma and are thereforeprominent targets for intraocular pressure-maintaining drugs.28−30 Isoforms hCA IX and hCA XII are overexpressed in cancerpatients and are therefore validated targets for cancer treatment.31 In contrast, the cytosolic hCA I isoformis off target and is inhibited by sulfonamides effectively.32 The assessed results for the inhibition of screenedisoforms and the selectivity index (SI) values of designed drug molecules 27–34 compared with the standard AAZ arementioned in Tables 1 and 2. Here, CYP24A1 is linked to cancer.