CYP24A1 and cancer: To discover novelcarbonic anhydrase (CA, EC 4.2.1.1) inhibitorsfor cancer treatment, a series of 4-{4-[(hydroxyimino)methyl]piperazin-1-yl}benzenesulfonamideswere designed and synthesized using SLC-0111 as the lead molecule.The developed novel compounds 27–34 were investigated for the inhibition of human (h) isoforms hCA I,hCA II, hCA IX, and hCA XII.