The Cancer Genome Atlas in cancer patients showed that the synthesis of cholesterol was mainly mediated by the genes hmgcr, mvk, pmvk, mvd, fdps, fdft1, sqle, lss, dhcr24, cyp51a1, tm7sf2, msmo1, nsdhl, hsd17b7, ebp, sc5d, and dhcr7 [29]. Here, NSDHL is linked to cancer.