The example depicted in Fig. 5B shows that the Receptor tyrosine kinase/RAS pathway, and the Notch and TGF-β pathways are frequently altered in AEL patients, and that the ABL Proto-Oncogene 1 (ABL1), NOTCH2, and TGF-β receptor 2 (TGFBR2) receptor genes are among the top mutated genes. Here, TGFB1 is linked to acute erythroid leukemia.