Age < 40 years, abnormal AST, max tumor size > 5 cm, positive MVI and low differentiated tumor were the main impacts of OS (Fig. 1C), while age < 40 years, AFP ≥ 400 ng/mL, max tumor size > 5 cm, positive MVI and low differentiated tumor were the major contributing factors of RFS (Fig. 1D). The gene discussed is AFP; the disease is neoplasm.