We found that the NLRP3 inflammasome was significantly activated after IH, and the expression of NLRP3 inflammasome (NLRP3, Cleaved Caspase1, and ASC) was significantly inhibited in IH neurons treating with miR-146a-5p up-regulated exosomes compared with unedited exosomes (Fig. 5c-d). Here, NLRP3 is linked to isolated hemihyperplasia.