Compared to normal samples, we observed that the APOF mRNA expression was significantly upregulated in lung adenocarcinoma (LUAD), low-grade glioma (LGG), PRAD and BRCA while downregulated in kidney renal papillary cell carcinoma (KIRP), pan-kidney cohort (KIPAN), kidney renal clear cell carcinoma (KIRC), LIHC, thyroid carcinoma (THCA), KICH and cholangiocarcinoma (CHOL) patients (Fig. 1A). The gene discussed is APOF; the disease is lung adenocarcinoma.