Interestingly, we found that PRAD was the only cancer type in which APOF expression levels were negatively correlated with age, combined with our finding that APOF expression levels were much higher in PRAD tumor tissues than in normal tissues, due to the fact that PRAD is the only cancer type in which aging has been identified as a direct risk factor among all cancer types [80]. Here, APOF is linked to prostate adenocarcinoma.