Animal model for diabetes mellitus represent a higher concentration of ANGPTL3 and patients with T2DM represent similar status for this hepatokine [25, 26], however, Zhao et al. demonstrated lower levels of ANGPTL3 in the female with T2DM compared to controls and no change between men with T2DM and control [27], this controversy might be a result from medications and difference in ethnic. This evidence concerns the gene ANGPTL3 and type 2 diabetes mellitus.