Collectively, the present study showed an in vivo relation of ANGPTL3 with markers of renal dysfunction and hypertriglyceridemia in patients with DN, which is in line with previous clinical and experimental studies and these findings suggested ANGPTL3 as a potential therapeutic target for renal dysfunction in patients with diabetes, although further interventional studies are required in this regard. The gene discussed is ANGPTL3; the disease is hypertriglyceridemia.