In a large cohort of colorectal cancers, the prognostic effect differed based on the spatial location of LAG3 + tumor-infiltrating lymphocytes (TILs), and showed poor CSS in cases with high intra-tumoral LAG3 + TILs and improved CSS when LAG3 was identified in stromal immune cells (Al-Badran et al. 2021). Here, LAG3 is linked to colorectal cancer.