Adipose tissue dysregulation contributes to the pathophysiology of a variety of metabolic disorders, including cardiovascular diseases, obesity, polycystic ovary syndrome (PCOS), and diabetes mellitus3,4 Recent studies in the rat model show that ADM and its receptors are expressed in adipose tissue5, administration of ADM induces hyperglycemia, which can be reversed by an ADM neutralizing antibody6. Here, ADM is linked to obesity due to melanocortin 4 receptor deficiency.