Some other CDK1 substrates act as tumor suppressors, including discs large MAGUK scaffold protein 1 (DLG1)131, F-box protein 5 (EMI1)132, sequestosome 1 (P62)133, EPH receptor A2 (EPHA2)134,135, and vestigial like family member 4 (VGLL4)136. Here, FBXO5 is linked to neoplasm.