NIK is regulated by TNF receptor-associated factor (TRAF)2 and TRAF3 in beta cells [12] and, of interest, TRAF3 SNPs associate with type 2 diabetes risk and body weight variables in genome-wide association studies (data mined from the National Human Genome Research Institute–European Bioinformatics Institute [NHGRI-EBI] GWAS Catalog; summary statistics accession ID: GCST90132184; GCST010557; GCST009001; GCST008996). The gene discussed is MAP3K14; the disease is type 2 diabetes mellitus.