Thereby, the present study aims to expose the therapeutic effect of mesenchymal stem cells (MSCs) and/or acitretin on NF-kB inflammatory signaling pathway-associated genes (TNFAIP1, TGF-βRII, IL-1β and IL-4) and its regulatory miRNAs namely, miR-146a and miR-155 in AD-like rat model. This evidence concerns the gene NFKB1 and Alzheimer disease.