Through the PI3K-Akt, HIF-1, and ErbB signaling pathways, curcuma regulates key targets that are involved in angiogenesis, cancer cell proliferation, metastasis, invasion, and chemotherapy resistance, including AKT1, TNF, STAT3, EGFR and HSP90AA1, in the treatment of OS. The gene discussed is HSP90AA1; the disease is cancer.