ESR1 and breast carcinoma: Multivariate Cox regression analysis among patients with ER+/HER2- breast cancer showed that there is a positive association between DRFS and TMEM doorway score (high vs mid/low) with a slightly stronger magnitude (HR 2.38 [95% CI 0.96–5.95]) but with borderline significance (p = 0.06) compared to entire cohort analysis.