PPARGC1A and sexually transmitted disease: Conversely, PGC1α deletion in peritoneal macrophages from VD(−) HSC recipients suppressed inflammatory cytokine release and improved adipose sensitivity in co-culture experiments with 3T3-L1 adipocytes (Fig. 4C, D), suggesting that activation of this inflammatory pathway in macrophages by in utero VD deficiency may be responsible for adipose IR.