Furthermore, compared to the control group, knockdown of LINC00641 increased the cellular ROS levels and the intracellular concentrations of both ferrous iron (Fe2+) and total iron (Fe) under the treatment of RSL3 (Fig. 6F–H), suggesting that LINC00641 downregulation could increase ferroptotic sensitivity in lung cancer cells. This evidence concerns the gene LINC00641 and lung carcinoma.