To investigate whether mesenchymal lung cancer cells were more sensitive to ferroptosis, we utilized flow cytometry to isolate cells with low E-cadherin and high N-cadherin level (referred to as A549-ElowNhigh) and cells with high E-cadherin and low N-cadherin level (referred to as A549-EhighNlow) (Supplementary Fig. S5C, D). The gene discussed is CDH2; the disease is lung cancer.