Higher expression of SAS-1 (SAS-1high) likely tracked IChigh, as this signature comprised IC-related genes (e.g., CCR7, IL7R; Fig. 2d) and higher baseline expression of SAS-1 associated with lower all-cause mortality hazards during acute COVID-19 as well as lower all-cause mortality hazards in the FHS (Fig. 2c, d). This evidence concerns the gene CCR7 and COVID-19.