USP8 and hepatocellular carcinoma: We tested the expression of USP8 in HCC cell lines (Huh-7, Hep3B, HepG2, PLC/PRF/5, 7404, LM3) and normal liver cell line (LO2), we observed that USP8 was highly expressed in HepG2 and LM3 cells (Fig. 1B).