Single-cell analysis of fibroblast lineages showed that LRRC15+ cells were enriched in arthritis, skin wound, fibrosis, and small and large pancreatic ductal adenocarcinoma, and these cells also showed high expression of CTHRC1 (Buechler et al, 2021). The gene discussed is LRRC15; the disease is pancreatic ductal adenocarcinoma.